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TRV-2026-0663Version 1 · Certified

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TRUVACE RECORD VERSION
record: TRV-2026-0663
version: 1
kind: certified
reason: Certified into the record
timestamp: 2026-08-06T06:25:57.896311Z
status: published
lens: trace
sector: health
headline: Evaluating Artificial Intelligence Translation Tools for Language Equivalence of Oncology-Informed Consent Forms From English to Spanish
dek: Approximately 8% of the US population speaks primary languages other than English. Limited English proficiency (LEP) contributes to under-representation of Hispanic patients in oncology clinical trials. Although certified translation services exist, they are time-consuming and costly. Artificial intelligence (AI)-generated translations of informed consent forms (ICFs) could provide low-cost alternatives, but data on accuracy and safety remain limited. We evaluated language equivalence of English-to-Spanish trans…
gain_title: General-purpose AI tool ChatGPT-4o achieved near-certified translation equivalence for English-to-Spanish oncology informed consent forms.
problem_title: Low-cost AI translations of oncology informed consent forms showed variable language equivalence and remain unsuitable for clinical use without human review.
trace_subject: English-to-Spanish translation equivalence of oncology clinical trial informed consent forms
gain_reading: General-purpose AI tool ChatGPT-4o achieved near-certified translation equivalence for English-to-Spanish oncology informed consent forms.
gain_evidence: ChatGPT-4o similarly demonstrated high equivalence (mean = 4.89, SD = 0.17)
problem_reading: Low-cost AI translations of oncology informed consent forms showed variable language equivalence and remain unsuitable for clinical use without human review.
problem_evidence: Low-cost AI translations of ICFs exhibited variable language equivalence compared with certified translations across several domains | While AI-generated translations are currently not suitable for clinical deployment without human review
quick_read: On August 5, 2026, a peer-reviewed study in JCO Oncology Practice evaluated AI translation of three oncology clinical trial informed consent forms from English to Spanish, comparing DeepL Pro, ChatGPT-4o, and a medically trained model Med_English2Spanish against certified translations using five equivalence domains scored by two bilingual physicians.

The findings matter because limited English proficiency contributes to under-representation of Hispanic patients in oncology trials, and low-cost AI could reduce barriers, but variable performance and safety concerns mean human review remains required and broader validation across more forms, languages, and raters is still needed.
limitation: Exploratory evaluation limited to three oncology ICFs and two physician raters, with variable equivalence across tools and domains.
tag: Automated dual reading
key_points: Study compared DeepL Pro, ChatGPT-4o, and Med_English2Spanish against certified translations for three oncology ICFs. | Equivalence scored on five-point Likert scale across Semantic, Idiomatic, Experiential, Conceptual, and Safety domains by two bilingual physicians. | Certified translations highest at mean 4.99, ChatGPT-4o at 4.89, DeepL Pro at 4.43, Med_English2Spanish lowest at 3.32. | Authors concluded AI translations not suitable for clinical deployment without human review but warrant further study to reduce language barriers.
rundown: Researchers tested English-to-Spanish translation of three oncology trial ICFs using DeepL Pro, ChatGPT-4o, and Med_English2Spanish versus certified translations, scoring five domains on a five-point Likert scale.

Two bilingual board-certified physicians scored independently with high inter-rater agreement (weighted kappa 0.95), finding certified translations at 4.99 mean, ChatGPT-4o at 4.89, DeepL Pro at 4.43, and Med_English2Spanish at 3.32.
sources:
- peer_reviewed | JCO Oncology Practice | https://doi.org/10.1200/op-26-00317 | 2026-08-05
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