aceSex differences in CT-FFR of myocardial bridging with or without atherosclerosis: an AI-based quantitative study
Background: Myocardial bridging (MB) is a prevalent coronary anomaly with potential links to major adverse cardiac events. While computed tomography-derived fractional flow reserve (FFRCT) offers a non-invasive functional assessment, current evidence predominantly treats MB as a homogeneous entity, overlooking potential sex differences in hemodynamic impact. Existing studies often fail to distinguish between isolated MB and MB with concomitant atherosclerosis, and rarely employ sex-stratified analyses. This stud…
An AI-based platform for CT-derived fractional flow reserve enabled noninvasive, sex-stratified quantification of hemodynamic impact in LAD myocardial bridging, showing distinct distal flow patterns and supporting risk stratification.
In patients with LAD myocardial bridging, longer bridging length increased risk of abnormal FFRCT, with a larger effect in females, and females with isolated bridging had more pronounced distal hemodynamic compromise.
Retrospective cohort limited to LAD-MB patients and findings described as preliminary, limiting generalizability beyond this anatomy and design.
Evidence
- Peer-reviewedQuantitative Imaging in Medicine and Surgery2026-07-01
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Truvace Impact Record TRV-2026-0331, v1: “Sex differences in CT-FFR of myocardial bridging with or without atherosclerosis: an AI-based quantitative study.” Truvace, 2026-07-20. /record/TRV-2026-0331 (accessed at citation time). sha256 1918293dc0b9efcf…
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