aceArtificial Intelligence for Evidence Synthesis of Emerging Biologics to Improve Skeletal Health in Osteogenesis Imperfecta: Systematic Review and Meta-Analysis
Background: Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by bone fragility and recurrent fractures. Emerging biologics demonstrate promise by targeting bone-remodeling pathways, yet evidence for their efficacy and safety remains fragmented and heterogeneous, and no prior systematic review in OI has incorporated artificial intelligence (AI) to synthesize it. Objective: This study aims to systematically evaluate the efficacy and safety of novel biologics in patients with OI using an AI-ass…
GPT-4o integrated into systematic review screening substantially accelerated evidence synthesis for osteogenesis imperfecta biologics while maintaining high sensitivity.
GPT-4o showed optimism and positional biases in risk-of-bias assessment because it relied on probabilistic language patterns rather than structured clinical reasoning.
Findings are constrained by a small and heterogeneous trial base, limiting generalizability of both efficacy estimates and AI performance.
Evidence
- Peer-reviewedJournal of Medical Internet Research2026-07-10
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Truvace Impact Record TRV-2026-0321, v1: “Artificial Intelligence for Evidence Synthesis of Emerging Biologics to Improve Skeletal Health in Osteogenesis Imperfecta: Systematic Review and Meta-Analysis.” Truvace, 2026-07-20. /record/TRV-2026-0321 (accessed at citation time). sha256 9efe60cc27b6979d…
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