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TRV-2026-0245Certified recordPeer-reviewed

Predictive value of the uric acid to high-density cholesterol ratio (UHR) combined with intact parathyroid hormone for protein-energy wasting after incident hemodialysis: a multicenter study

Protein-energy wasting (PEW) is common in incident hemodialysis patients and linked to poor outcomes. The uric acid/HDL-cholesterol ratio (UHR) and intact parathyroid hormone (iPTH) relate to metabolic, inflammatory, and nutritional disturbances, but their value for predicting PEW in incident hemodialysis is unclear. This retrospective multicenter study included 863 incident hemodialysis patients. PEW was defined according to the International Society of Renal Nutrition and Metabolism criteria. UHR and iPTH were…

Health · G Space — documented gain · certified 2026-07-17 · v1 · article view · machine-readable

Current reading — gain

XGBoost model integrating UHR and iPTH predicted protein-energy wasting in incident hemodialysis patients with AUC 0.801, enabling individualized risk assessment.

What this doesn’t fix

Retrospective design limits causal inference and generalizability beyond the 863 incident hemodialysis patients studied, with nonlinear and mediated relationships requiring further validation.

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Truvace Impact Record TRV-2026-0245, v1: “Predictive value of the uric acid to high-density cholesterol ratio (UHR) combined with intact parathyroid hormone for protein-energy wasting after incident hemodialysis: a multicenter study.” Truvace, 2026-07-17. /record/TRV-2026-0245 (accessed at citation time). sha256 87e1be447e2baef6…

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