Truace
Subscribe

EXPRESS: Relation between Albumin-Corrected Anion Gap and In-Hospital Mortality in Patients with Traumatic Lung Injury: A Multicenter Retrospective Cohort Study and the Development of Machine Learning-Based Prediction Models

Background The anion gap is primarily utilized as an indicator for evaluating acid-base imbalances in critically ill patients. However, its accuracy is reduced in such patients due to low albumin levels. The albumin-corrected anion gap (ACAG) enhances the accuracy of assessing acid-base imbalances. Individuals with traumatic lung injury (TLI) in the intensive care unit (ICU) often have severe metabolic acidosis and hypoalbuminemia. Nevertheless, the association of ACAG with the prognosis of patients with TLI is…

By the Truvace desk1 min read1 sourcePeer-reviewedTRV-2026-0846· cite & verify
EXPRESS: Relation between Albumin-Corrected Anion Gap and In-Hospital Mortality in Patients with Traumatic Lung Injury: A Multicenter Retrospective Cohort Study and the Development of Machine Learning-Based Prediction Models
An introduction to modern therapeutics; being the Croonian lectures on the relationship between chemical structure and physiological action in relation to the prevention, control, and cure of disease by Brunton, T. Lauder (Thomas Lauder), Sir, 1844-1916. Public domain

In brief

Background The anion gap is primarily utilized as an indicator for evaluating acid-base imbalances in critically ill patients. However, its accuracy is reduced in such patients due to low albumin levels.

Data from the MIMIC-IV database were utilized as the training set to develop machine learning-based models. The Boruta algorithm was adopted for the selection of feature variables.

Main points

  1. Background The anion gap is primarily utilized as an indicator for evaluating acid-base imbalances in critically ill patients.
  2. However, its accuracy is reduced in such patients due to low albumin levels.
  3. The albumin-corrected anion gap (ACAG) enhances the accuracy of assessing acid-base imbalances.

The problem

EXPRESS: Relation between Albumin-Corrected Anion Gap and In-Hospital Mortality in Patients with Traumatic Lung Injury: A Multicenter Retrospective Cohort Study and the Development of Machine Learning-Based Prediction Models: Elevated ACAG was substantially linked to a high risk of mortality in individuals with TLI (hazard ratio (HR) [95% confidence interval (CI)] = 1.115 [1.037-1.199]).

The rundown

The albumin-corrected anion gap (ACAG) enhances the accuracy of assessing acid-base imbalances. Individuals with traumatic lung injury (TLI) in the intensive care unit (ICU) often have severe metabolic acidosis and hypoalbuminemia.

Sources

  1. Peer-reviewedJournal of Investigative Medicine2026-08-21

The debate