+ HEALTH Background Laryngeal cancer is a significant global health issue with high mortality, and early diagnosis is…+ LABOR This scoping review consolidates existing technology-enabled interventions for preventing and responding to a…+ HEALTH Background Assessment of pulmonary vascularity on chest radiographs (CXRs) in congenital heart disease (CHD)…− HEALTH Most artificial intelligence (AI) models used in radiology are black boxes-they produce predictions without e…− HEALTH Background The anion gap is primarily utilized as an indicator for evaluating acid-base imbalances in critica…+ HEALTH Introduction Combat Medical Technicians (CMTs) are central to military primary care but have limited opportun…+ HEALTH Objective This study aimed to evaluate the structural characteristics of mandibular alveolar bone in patients…+ MEDIA & ARTS Look, we all want Brooke Shields to be in gainful employment. We all want her to have a fabulous third act to…
TruaceTracing the truth around AISaturday, August 22, 2026
Subscribe
Health·P Space·Evidence-backed problem·Published 2026-08-22

EXPRESS: Relation between Albumin-Corrected Anion Gap and In-Hospital Mortality in Patients with Traumatic Lung Injury: A Multicenter Retrospective Cohort Study and the Development of Machine Learning-Based Prediction Models

Abstract: Background The anion gap is primarily utilized as an indicator for evaluating acid-base imbalances in critically ill patients. However, its accuracy is reduced in such patients due to low albumin levels. The albumin-corrected anion gap (ACAG) enhances the accuracy of assessing acid-base imbalances. Individuals with traumatic lung injury (TLI) in the intensive care unit (ICU) often have severe metabolic acidosis and hypoalbuminemia. Nevertheless, the association of ACAG with the prognosis of patients with TLI is…

TRV-2026-0846Peer-reviewedPermanent record — cite & verify
EXPRESS: Relation between Albumin-Corrected Anion Gap and In-Hospital Mortality in Patients with Traumatic Lung Injury: A Multicenter Retrospective Cohort Study and the Development of Machine Learning-Based Prediction Models

An introduction to modern therapeutics; being the Croonian lectures on the relationship between chemical structure and physiological action in relation to the prevention, control, and cure of disease by Brunton, T. Lauder (Thomas Lauder), Sir, 1844-1916. Public domain

The quick read

Background The anion gap is primarily utilized as an indicator for evaluating acid-base imbalances in critically ill patients. However, its accuracy is reduced in such patients due to low albumin levels.

Data from the MIMIC-IV database were utilized as the training set to develop machine learning-based models. The Boruta algorithm was adopted for the selection of feature variables.

Main points
  • Background The anion gap is primarily utilized as an indicator for evaluating acid-base imbalances in critically ill patients.
  • However, its accuracy is reduced in such patients due to low albumin levels.
  • The albumin-corrected anion gap (ACAG) enhances the accuracy of assessing acid-base imbalances.
Problem

EXPRESS: Relation between Albumin-Corrected Anion Gap and In-Hospital Mortality in Patients with Traumatic Lung Injury: A Multicenter Retrospective Cohort Study and the Development of Machine Learning-Based Prediction Models: Elevated ACAG was substantially linked to a high risk of mortality in individuals with TLI (hazard ratio (HR) [95% confidence interval (CI)] = 1.115 [1.037-1.199]).

The rundown

The albumin-corrected anion gap (ACAG) enhances the accuracy of assessing acid-base imbalances. Individuals with traumatic lung injury (TLI) in the intensive care unit (ICU) often have severe metabolic acidosis and hypoalbuminemia.

Sources

Reader signal

How should this claim be treated?

The debate