aceCAUSAL artificial intelligence and data-driven decision intelligence in personalized medicine: a review of healthcare informatics systems
Abstract: This review examines the integration of causal artificial intelligence (AI) and data-driven decision intelligence within healthcare informatics systems to advance personalized medicine and clinical decision-making. A narrative review methodology was employed, synthesizing interdisciplinary literature from major databases, including PubMed, Scopus, Web of Science, IEEE Xplore, and ScienceDirect. Studies focusing on causal inference, decision intelligence, and healthcare informatics applications in personalized me…
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On 2026-08-13, a review in Personalized Medicine examined integration of causal artificial intelligence and data-driven decision intelligence within healthcare informatics to advance personalized medicine. Using a narrative review of literature from PubMed, Scopus, Web of Science, IEEE Xplore and ScienceDirect, the authors synthesized evidence on causal inference methods and clinical applications.
The synthesis matters because it shifts focus from correlational prediction to causal estimation of treatment effects and simulation of outcomes for individual patients, with reported gains in prediction accuracy and interpretability that could foster clinician trust. As of the publication date, benefits are framed as potential and dependent on infrastructure maturity, leaving uncertainty about measured improvements in outcomes across diverse health systems.
- Narrative review synthesized literature from PubMed, Scopus, Web of Science, IEEE Xplore, and ScienceDirect on causal inference and decision intelligence.
- Integration of multimodal data including electronic health records, genomic data, and real-time monitoring improves prediction accuracy for tailored strategies.
- Causal models were found to improve interpretability, fostering clinician trust and transparent decision-making.
- Interoperable systems and data warehouses identified as critical enablers for deploying causal analytics in clinical settings.
Causal AI integrated into healthcare informatics systems improves personalized clinical decision-making by estimating individual treatment effects and simulating intervention outcomes.
The rundown
The authors conducted a narrative review, extracting data on methodological approaches, healthcare settings, analytical techniques, and clinical applications, followed by thematic synthesis across major databases.
Findings emphasize that robust healthcare informatics infrastructures, including interoperable systems and data warehouses, are critical enablers, and that multimodal integration supports tailored treatment strategies at the individual patient level.
Sources
- Peer-reviewedPersonalized Medicine2026-08-13
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